On 13 November 2017, a dinner symposium titled ‘Multiple Sclerosis Case Sharing Evening Lecture’ was held at The Mira Hong Kong. Our society was delighted to learn from Prof. Antonio Uccelli again, who kindly stayed after the ASM to give this talk. In this symposium, Prof. Uccelli illustrated several cases where first line therapy could serve as better options for certain patients, and highlighted the importance of a tailor-made approach to MS treatment.